Letter to the Editor
There remains substantial evidence to warrant great concern over the poor efficiency and specificity of clustered regularly interspaced short palindromic repeats (CRISPR)-mediated genetic modification (GM), despite relatively minor improvements compared to other GM methods. These issues cause persistent, adverse, ethical, and scientific consequences for GM animals, which may never be sufficiently resolvable.
Bailey, J. (2019). CRISPR-Mediated Gene Editing: Scientific and Ethical Issues. Trends in biotechnology. https://doi.org/10.1016/j.tibtech.2019.05.002