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Submissions from 2019

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Recent efforts to elucidate the scientific validity of animal-based drug tests by the pharmaceutical industry, pro-testing lobby groups, and animal welfare organisations, Jarrod Bailey

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Adaptation of the Systematic Review Framework to the Assessment of Toxicological Test Methods: Challenges and Lessons Learned With the Zebrafish Embryotoxicity Test, Martin L. Stephens, Sevcan Gül Akgün-Ölmez, Sebastian Hoffman, Rob de Vries, Burkhard Flick, Thomas Hartung, Manoj Lalu, Alexandra Maertens, Hilda Witters, Robert Wright, and Katya Tsaioun

Submissions from 2018

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Diffusion through the ex vivo vitreal body – Bovine, porcine, and ovine models are poor surrogates for the human vitreous, Sara Shafaie, Victoria Hutter, Marc B. Brown, Michael T. Cook, and David Y.S. Chau

Submissions from 2017

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Wound healing in rabbit corneas after flapless refractive lenticule extraction with a 345 nm ultraviolet femtosecond laser, Christian M. Hammer, Corinna Petsch, Jörg Klenke, Katrin Skerl, Christian Wüllner, Christof Donitzky, Friedrich Paulsen, Michael Scholz, Theo Seiler, Friedrich E. Kruse, and Johannes Menzel-Severing

Submissions from 2016

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Animal-Friendly Affinity Reagents: Replacing the Needless in the Haystack, A. C. Gray, S. S. Sidhu, P. C. Chandrasekera, C. F.M. Hendriksen, and C. A.K. Borrebaeck

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Act on the Registration and Evaluation of Chemicals (K-REACH) and replacement, reduction or refinement best practices, Soojin Ha, Troy Seidle, and Kyung-Min Lim

Submissions from 2015

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Predicting Human Drug Toxicity and Safety via Animal Tests: Can Any One Species Predict Drug Toxicity in Any Other, and Do Monkeys Help?, Jarrod Bailey, Michelle Thew, and Michael Balls

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Lessons from Toxicology: Developing a 21st‑Century Paradigm for Medical Research, Gill Langley, Christopher P. Austin, Anil K. Balapure, Linda S. Birnbaum, John R. Bucher, Julia Fentem, Suzanne C. Fitzpatrick, John R. Fowle III, Robert J. Kavlock, Hiroaki Kitano, Brett A. Lidbury, Alysson R. Muotri, Shuang-Qing Peng, Dmitry Sakharov, Troy Seidle, Thales Trez, Alexander Tonevitsky, Anja van de Stolpe, Maurice Whelan, and Catherine Willett

Submissions from 2014

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An Analysis of the Use of Animal Models in Predicting Human Toxicology and Drug Safety, Jarrod Bailey, Michelle Thew, and Michael Balls

Submissions from 2013

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An Analysis of the Use of Dogs in Predicting Human Toxicology and Drug Safety, Jarrod Bailey, Michelle Thew, and Michael Balls

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Food for Thought … Mechanistic Validation, Thomas Hartung, Sebastian Hoffman, and Martin Stephens

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Can Acute Dermal Systemic Toxicity Tests Be Replaced With Oral Tests? A Comparison of Route-Specific Systemic Toxicity and Hazard Classifications Under the Globally Harmonized System of Classification and Labelling of Chemicals (GHS), Nigel P. Moore, David J. Andrew, Donald L. Bjerke, Stuart Creton, David Dreher, Thomas Holmes, Pilar Prieto, Troy Seidle, and Tim G. Rowan

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Evidence-based Toxicology for the 21st Century: Opportunities and Challenges, Martin L. Stephens, Melvin E. Andersen, Richard A. Becker, Kellyn Betts, Kim Boekelheide, Ed Carney, Robert Chapin, Dennis Devlin, Suzanne C. Fitzpatrick, John R. Fowle III, Patricia Harlow, Thomas Hartung, Sebastian Hoffman, Michael P. Holsapple, Abigail Jacobs, Richard Judson, Olga Naidenko, Tim Pastoor, Grace Patlewicz, Andrew Rowan, Roberta Scherer, Rashid Shaikh, Ted Simon, Douglas Wolf, and Joanne Zurlo

Submissions from 2012

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A Roadmap for the Development of Alternative (Non-Animal) Methods for Systemic Toxicity Testing, David Basketter, Harvey Clewell, Ian Kimber, Annamaria Rossi, Bas Blaauboer, Robert Burrier, Mardas Daneshian, Chantra Eskes, Alan Goldberg, Nina Hasiwa, Sebastian Hoffmann, Joanna Jaworska, Thomas B. Knudsen, Robert Landsiedel, Marcel Leist, Paul Locke, Gavin Maxwell, James McKim, Emily McVey, Gladys Ouédraogo, Grace Patlewicz, Olavi Pelkonen, Erwin Roggen, Costanza Rovida, Irmela Ruhdel, Michael Schwarz, Andreas Schepky, Greet Schoeters, Nigel Skinner, Kerstin Trentz, Marian Turner, Philippe Vanparys, James Yager, Joanne Zurlo, and Thomas Hartung

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The Use of Biomarkers of Toxicity for Integrating In Vitro Hazard Estimates Into Risk Assessment for Humans, Bas Blaauboer, Kim Boekelheide, Harvey Clewell, Mardas Daneshian, Milou M.L. Dingemans, Alan M. Goldberg, Marjoke Heneweer, Joanna Jaworska, Nynke I. Kramer, Marcel Leist, Hasso Seibert, Emanuela Testai, Rob J. Vandebriel, James D. Yager, and Joanne Zurlo

Submissions from 2011

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Examining the Regulatory Value of Multi-Route Mammalian Acute Systemic Toxicity Studies, Troy Seidle, Pilar Prieto, and Anna Bulgheroni

Submissions from 2010

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The Current Scientific and Legal Status of Alternative Methods to the LD50 Test for Botulinum Neurotoxin Potency Testing, Sarah Adler, Gerd Bicker, Hans Bigalke, Christopher Bishop, Jörg Blümel, Dirk Dressler, Joan Fitzgerald, Frank Gessler, Heide Heuschen, Birgit Kegel, Andreas Luch, Catherine Milne, Andrew Pickett, Heidemarie Ratsch, Irmela Ruhdel, Dorothea Sesardic, Martin Stephens, Gerhard Stiens, Peter D. Thornton, René Thürmer, Martin Vey, Horst Spielmann, Barbara Grune, and Manfred Liebsch

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Cross-Sector Review of Drivers and Available 3Rs Approaches for Acute Systemic Toxicity Testing, Troy Seidle, Sally Robinson, Tom Holmes, Stuart Creton, Pilar Prieto, Julia Scheel, and Magda Chlebus

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A Modular One-Generation Reproduction Study as a Flexible Testing System for Regulatory Safety Assessment, Richard Vogel, Troy Seidle, and Horst Spielmann

Submissions from 2008

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Developmental Toxicity Testing: Protecting Future Generations?, Jarrod Bailey

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Non-Animal Methodologies within Biomedical Research and Toxicity Testing, Andrew Knight

Submissions from 2007

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The Development of New Concepts for Assessing Reproductive Toxicity Applicable to Large Scale Toxicological Programmes, S. Bremer, C. Pellizzer, S. Hoffmann, T. Seidle, and T. Hartung

Submissions from 2006

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Animal Carcinogenicity Studies: 1. Poor Human Predictivity, Andrew Knight, Jarrod Bailey, and Jonathan Balcombe

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Animal Carcinogenicity Studies: 2. Obstacles to Extrapolation of Data to Humans, Andrew Knight, Jarrod Bailey, and Jonathan Balcombe

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Animal Carcinogenicity Studies: 3. Alternatives to the Bioassay, Andrew Knight, Jarrod Bailey, and Jonathan Balcombe

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Animal Carcinogenicity Studies: Implications for the REACH System, Andrew Knight, Jarrod Bailey, and Jonathan Balcombe

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Cancerous Contradictions: The Mis-Regulation of Human Carcinogens Based on Animal Data, Andrew Knight, Jarrod Bailey, and Jonathan Balcombe

Submissions from 2005

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Which Drugs Cause Cancer?, Andrew Knight, Jarrod Bailey, and Jonathan Balcombe

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LD50 Testing of Botulinum Toxin for Use as a Cosmetic, Martin L. Stephens and Michael Balls

Submissions from 2004

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An Evaluation of the US High Production Volume (HPV) Chemical-testing Programme: A Study in (Ir)Relevance, Redundancy and Retro Thinking, Andrew Nicholson, Jessica Sandler, and Troy Seidle

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Ideology Masquerading as Science: The Case of Endocrine Disrupter Screening Programmes, Troy Seidle

Submissions from 2003

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Toxicology and New Social Ethics for Animals, Bernard E. Rollin

Submissions from 2001

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Compendium of Chemical Carcinogens by Target Organ: Results of Chronic Bioassays in Rats, Mice, Hamsters, Dogs, and Monkeys, Lois Swirsky Gold, Neela B. Manley, Thomas H. Sloane, and Jerrold M. Ward

Submissions from 1991

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The Development of the Draize Test for Eye Toxicity, John Parascandola

Submissions from 1983

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A new approach to practical acute toxicity testing, Dietrich Lorke