Lynne U. Sneddon, Javier Lopez-Luna, David C.C. Wolfenden, Matthew C. Leach, Ana M. Valentim, Peter J. Steenbergen, Nabila Bardine, Amanda D. Currie, Donald M. Broom, and Culum Brown, Fish sentience denial: Muddying the waters


The increasing work using fish as a model organism calls for a better understanding of their sentience. While growing evidence suggests that pain and emotionality exist in zebrafish, many deniers continue to ignore the evidence. Here we revisit the main conceptual breakthroughs in the field that argue clearly for pain and emotionality. We call for an end to denial and a focus on studying the mechanisms of fish pain and emotionality, and their translational relevance to human conditions.

Author Biography

Konstantin A. Demin, doctoral candidate, Saint-Petersburg State University and Research Assistant, Almazov National Medical Research Centre works in biological psychiatry and drug discovery. His main focus is experimental models of stress, anxiety and depression as well as CNS drug-evoked conditions using zebrafish as a model organism. Researchgate

Anton M. Lakstygalstudied rodent CNS models at Saint Petersburg State University and is noe involved in preclinical bioscreening studies in zebrafish at the Russian Research Center for Radiology and Surgical Technologies (St. Petersburg). Researchgate

Allan V. Kalueff, neuroscientist and pharmacologist, is Director of the ZENEREI Research Center (New Orleans, USA), Professor of Neuroscience and Pharmacology at Southwest University (Chongqing, China), Professor of Neuroscience at Saint Petersburg State University, Leading Researcher at Almazov National Medical Research Centre, Ural Federal University and Institute of Physiology and Fundamental Medicine (Russia) and President of the International Stress and Behavior Society (ISBS). Researchgate.ZFIN lab.