All research facilities must submit an annual report on laboratory animal use to the U.S. Department of Agriculture Animal Care Staff as part of the legal requirements of the Federal Laboratory Animal Welfare Act (P.L. 89-544) and its subsequent amendments. This report (USDA: V.C. Form 18-23, Annual Report of Research Facility) must include an explanation of the scientific bases for conducting any research and tests that involve unalleviated distress (the "Pain-No Drugs" situation) in animal subjects. In some cases, only one of these reports is required.
Cass, J. M.
"How to Compose a Laboratory Animal Use Report for the USDA,"
International Journal for the Study of Animal Problems: Vol. 3:
2, Article 8.
Available at: https://www.wellbeingintlstudiesrepository.org/ijsap/vol3/iss2/8